Thesis Title

Part 1. Analysis of Cocaine and its Metabolites using LC and MS
Part 2. Mass Spectrometry of Nucleic Acids

Degree Conferred December 1998

Present Address

R.W. Johnson Pharmaceutical Research Institute
Welsh and McKean Roads
Spring House, PA 19477

Phone: (215) 628-5360
pwang9@prdus.jnj.com

Publications

P.P. Wang, L.B. Martin and M.G. Bartlett
"Electrospray collision-induced dissociation mass spectra of positively-charged oligonucleotides."
Rapid Communications in Mass Spectrometry, 11, 846-856 (1997).

L.P. Kotra, P.P. Wang, M.G. Bartlett, K. Shanmuganathan, Z. Xu, S. Cavalcanti, M.G. Newton and C.K. Chu
"4-Azido-2-pyrimidinone Nucleosides and Related Chemistry."
Journal of Organic Chemistry, 62, 7267-7271 (1997).

H. Zhang, P.P. Wang, M.G. Bartlett and J.T. Stewart
"HPLC determination of cisatracurium besylate and propofol mixtures with LC-MS identification of degradation products."
Journal of Pharmaceutical and Biomedical Analysis, 16, 1241-1249 (1998).

P.P. Wang, H. Zhang, J.T. Stewart and M.G. Bartlett
"Simultaneous Detection of Cisatracurium, its Degradation Products and Propofol Using Positive Ion Detection Followed by Negative Detection in a Single LC/MS Run."
Journal of Pharmaceutical and Biomedical Analysis, 17, 547-553 (1998).

P.P. Wang and M.G. Bartlett
"The Collision-Induced Dissociation Mass Spectra of Cocaine, its Metabolites and Pyrolysis Products."
Journal of Mass Spectrometry, 33, 961-967 (1998).

P.P. Wang and M.G. Bartlett
"Identification and Quantitation of Cocaine-N-oxide: A Thermally Labile Metabolite of Cocaine."
Journal of Analytical Toxicology, 23, 62-66 (1999).

P.P. Wang, L.P. Kotra, C.K. Chu and M.G. Bartlett
"Structure Determination of 4-Azido-2-pyrimidinone Nucleoside Analogs Using Mass Spectrometry."
Journal of Mass Spectrometry, 34, 724-732 (1999).

Y. Xia, P.P. Wang, K.L. Busch, H.M. Solomon and M.G. Bartlett
“Analysis of Cocaine and Cocaine Metabolites in Meconium by LC-MS/MS.”
Analytical Chemistry, 72, 764-771 (2000).

K. Srinivasan, P.P. Wang, A.T. Eley, C.A. White and M.G. Bartlett
“Liquid Chromatography-Tandem Mass Spectrometry Analysis of Cocaine and its Metabolites From Blood, Amniotic Fluid, Placental and Fetal Tissue:
Study of the Metabolism and Distribution of Cocaine in the Pregnant Rats.”
Journal of Chromatography B: Biomedical Applications, 745, 287-303 (2000).