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Drug Discovery Group |
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Accomplishments |
Dr. Chu and his collaborators discovered five chemotherapeutic agents
(see structures below) against cancer, AIDS and hepatitis B virus, out of which
three compounds are currently undergoing clinical trials and two are at the
preclinical stage.
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In
the spring of 2003, L-OddC (Troxatyl) has entered the Phase II clinical
trials as anticancer agent against various forms of cancer.
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DAPD (Amdoxovir), a dual antiviral agent for AIDS and hepatitis B
virus, is currently undergoing Phase II clinical trials as anti-HIV agent.
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L-FMAU (Clevudine) is
undergoing Phase III clinical trials as anti-HBV agent. It is found to be
extremely potent in woodchucks and clinical studies.
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DOT was discovered as
an anti-HIV agent for drug resistant HIV mutants. It is under preclinical
stage.
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Comments, Suggestions, Questions or Requests for Reprints
Last Update: 10/18/07