Alvin V. Terry, Jr., Ph.D.

Associate Professor and Director

Program in Clinical and Experimental Therapeutics
University of Georgia College of Pharmacy
CJ-1020, Medical College of Georgia
Augusta, Georgia 30912-2450
E-mail: aterry@mail.mcg.edu

Education:

1982   B.S. Pharmacy
Medical University of South Carolina, Charleston, S.C.
1991   Ph.D. Pharmacology
University of South Carolina, Columbia, S.C.
1991-92   Postdoctoral Fellow
Medical College of Georgia, Augusta, GA

Research Interests:

My research interests focus on the role of central cholinergic receptors in the neurodegeneration and cognitive decline associated with age-related disorders of memory including Alzheimer's Disease, Parkinson's Disease, and Dementia with Lewy Bodies. Using rodent and non-human primate models, the role of high affinity nicotinic acetylcholinergic receptors (i.e., the heteromeric a4b2 subtype) in age-related neurodegeneration is currently being investigated as well the role of this receptor as a potential target for neurotrophic, neuroprotective, and cognitive enhancing compounds.

Selected Recent Publications

Terry, A.V.,Jr., Buccafusco,J.J., Jackson,W.J., Zagrodnik,S., Evans-Martin,F.F., and Decker,M.W. Effects of stimulation or blockade of central nicotinic-cholinergic receptors on performance of a novel version of the rat stimulus discrimination task. Psychopharmacology,123:172-181,1996.

Terry,A.V.,Jr., Buccafusco,J.J., Prendergast,M.A., Jackson,W.J., Fontana,D.L., Wong,E.H.F., Whiting,R.L., and Eglen,R.M. The 5-HT3 Receptor Antagonist,RS-56812, Enhances Delayed Matching Performance in Monkeys. NeuroReport,8:49-54,1996.

Prendergast,M.A., Terry,A.V.,Jr., and Buccafusco,J.J. Chronic, low-level exposure to diisopropylfluorophosphate causes protracted impairment of spatial navigation learning. Psychopharmacology,129:183-191,1997.

Terry,A.V.,Jr., Buccafusco, and Decker,M.W. Cholinergic Channel Activator, ABT-418 Enhances Delayed Response Accuracy in Rats. Drug Development Research 40:304-312.1997.

Terry,A.V.,Jr., Buccafusco,J.J., Prendergast,M.A., Jackson,W.J., Fontana,D.L., Wong,E.H.F., Whiting,R.L., and Eglen,R.M. Enhanced Delayed Matching Performance in Younger and Older Macaques administered the 5-HT4 Receptor Agonist, RS-17017, Psychopharmacology 135(4):407-415;1998.

Prendergast,M.A., Terry,A.V.,Jr., and Buccafusco,J.J. Effects of chronic, low-level organophosphate exposure on delayed recall, discrimination, and spatial learning in monkeys and rats. Neurotoxicology and Teratology 20(2),115-122,1998.

Terry, A.V.,Jr., Williamson,R., Gattu,M., Beach,J.W., McCurdy,C.R., Sparks,J.A., and Pauly,J.R. Lobeline and structurally simplified analogs exhibit differential agonist activity and sensitivity to antagonist blockade when compared to nicotine. Neuropharmacology 37(1),93-102,1998.

Metting,T.L., Burgio,D.E., Terry,A.V.,Jr., Beach,J.W., McCurdy,C.R., and Allen,D.D. Inhibition of brain choline uptake by isoarecolone and lobeline derivatives: implications for potential vector-mediated brain drug delivery. Neuroscience Letters 258,25-28,1998.

Terry,A.V.,Jr., M. Gattu,M., Buccafusco,J.J., Sowell,J.W., and Kosh,J.W. Ranitidine Analog, JWS-USC-75IX, Enhances Memory-Related Task Performance in Rats. Drug Development Research,47(2):97-106,1999.

Terry, A.V.,Jr., Buccafusco,J.J. and Prendergast,M.A. Dose Specific Improvements in Memory-Related Task Performance by Rats and Aged Monkeys Administered the Nicotinic Antagonist, Mecamylamine. Drug Development Research,47(3):127-136,1999.

Clarke,M.S.F., Prendergast,M.A and Terry,A.V.,Jr. Plasma Membrane Ordering Agent (PF-68) Reduces Neurotransmitter Uptake and Release and Produces Learning and Memory Deficits in Rats. Learning and Memory,6:634-649,1999.

Buccafusco,J.J., Stone,J.D., Terry,A.V.,Jr., Pauly,J.R., and Prendergast,M.A. Selective Effects of Sub-Acute, Chronic Exposure to the Organophosphate DFP on the Expression of Cholinergic Receptor Subtypes in Rats: Reversal of the Deficit in a Spatial Memory Task by Nicotine. Brain Research 882: 9-18, 2000.

Buccafusco,J.J., and Terry,A.V.,Jr. Multiple CNS Targets for Eliciting Beneficial Effects on Memory and Cognition. Journal of Pharmacology and Experimental Therapeutics 295: 438-446, 2000.

Terry,A.V.,Jr., Hernandez,C.M., and Buccafusco,J.J., and Gattu, M. Deficits in Spatial Learning and Nicotinic-Acetylcholine Receptors in Older, Spontaneously Hypertensive Rats. Neuroscience 101: 357-368, 2000.

Terry, A.V., Jr., Hernandez, C. M., and Buccafusco, Dahl-salt sensitive and salt-resistant rats: examination of learning and memory performance, blood pressure, and the expression of central nicotinic-acetylcholine receptors. Neuroscience 103: 351-363, 2001.

Jonnala, R.R., Terry, A.V., Jr. and Buccafusco, J.J.: Nicotine increases the expression of high affinity nerve growth factor receptors both in vitro and in vivo. Life Sciences 70: 1543-1554, 2002.

Buccafusco, J.J., Terry, A.V., Jr. and Murdoch, P.B.: A computer assisted cognitive test battery for aged monkeys. Joournal of Molecular Neuroscience19:179-185, 2002. .

Jonnala, R.R., Graham, J.H.,III, Terry, A.V., Jr., Beach, J.W., Young, J.A. and Buccafusco, J.J.: Relative Levels of Cytoprotection Produced by Analogs of Choline and the Role of a7-nicotinic Acetylcholine Receptors. Synapse (in press).

Terry, A.V., Jr., V.B. Risbrough, V.B., Buccafusco, J.J., Menzaghi, F. "Effects of (±)-4-{[2-(1-Methyl-2-pyrrolidinyl)ethyl]thio}phenol Hydrochloride (SIB-1553A), a selective ligand for nicotinic acetylcholine receptors in tests of visual attention and distractibility in rats and monkeys". Journal of Pharmacology and Experimental Therapeutics 301:284-292, 2002.

Terry, A.V., Jr., Buccafusco, J.J., Borsini, F., and Leusch, A. “Memory-Related Task Performance by Aged Rhesus Monkeys Administered the Muscarinic M1-preferring Agonist, Talsaclidine. Psychopharmacology 162: 292-300, 2002

MCG Alzheimer's Research Center (ARC)

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