Randall L. Tackett, Ph.D.

Professor and Graduate Coordinator

Department of Clinical and Administrative Pharmacy
University of Georgia College of Pharmacy
Athens, GA 30602-2356
E-mail: rtackett@rx.uga.edu

Education:

1975   B.S. Biology
Jacksonville University
1977   M.S. Pharmacology
Auburn University
1979   Ph.D. Pharmacology
University of Georgia
1979-81   Postdoctoral Fellowship, Pharmacology
Medical University of South Carolina

Research Interests:

Racial and Gender differences in cardiovascular disease; vascular biology and production of free radicals; interaction of drugs with the autonomic nervous system; mechanism of action of substances of abuse; adverse drug reactions

Selected Recent Publications

Tackett, R. L., Webb, J. G. and Privitera, P. J. Cerebroventricular Propranolol Elevates Cerebrospinal Fluid Norepinephrine and Lowers Blood Pressure. Science 213: 911-913, 1981.

Jones, L. F. and Tackett, R. L. Chronic Cocaine Treatment Enhances the Responsiveness of the Left Descending Coronary Artery and the Femoral Artery to Vasoactive Substances. J. Pharmacol. Exp. Ther. 255: 1366-1370, 1990.

Barber, D. A., Zumbro, G. L., Rubin, J. W., and Tackett, R. L. The Use of Methylene Blue as an Extravascular Surgical Marker Impairs Vascular Responses of Human Saphenous Veins. J. Thor. Cardiovasc. Surg. 109: 21-29, 1995.

Barber, D.A., Do, N.H., Tackett, R.L. and Capomacchia, A.C. Non-superoxide Lucigenin-Enhanced Chemiluminescence From Phospholipids and Human Saphenous Veins. Free Rad. Biol. Med. 18: 565-69, 1995.

Ergul, A., Tackett, R.L., and Puett, D. Identification of Receptor Binding and Activation Sites in Endothelin-1 Using Site Directed Mutagenesis. Circ. Res. 77: 1087-94, 1995.

Shoemaker, K., Rubin, J.W., Zumbro, G.L. and Tackett, R.L. Evans Blue and Gentian Violet: Alternatives to Methylene Blue as a Surgical Marker Dye. J. Thor. Cardiovasc. Surg. 112: 542-544, 1996.

Zhao, L and Tackett, R.L. Oxidized Low Density Lipoprotein Inhibits Acetylcholine-Induced Vasorelaxation and Increases 5-HT-Induced Vasoconstriction in Isolated Human Saphenous Vein. J. Pharmacol. Exp. Ther. 284: 637-43, 1998.

Ergul, A., Shoemaker, K., Puett, D., and Tackett, R.L. Gender Differences in the Expression of Endothelin Receptors in Human Saphenous Veins. J Pharmacol. Exp. Ther. 285: 511-17, 1998.

Severson, K. R. and Tackett, R. L. Enhanced Hemodynamic Response to [D-ala2, D-met5]-Methionine Enkephalin (DAME) in Streptozotocin-Induced Diabetic Rats Is Reversed By Insulin Replacement. Life Sci. 62: 2219-30, 1998.

Josey, E. and Tackett, R.L. St. John's Wort: A New Alternative For Depression. Int J Clin. Pharmacol. Ther. 37:111-19, 1999.

Ergul, A., Tackett, R.L., and Puett, D. Distribution of Endothelin Receptors in Saphenous Veins of African Americans: Implications of Racial Differences. J Cardiovasc Pharmacol. 34: 327-32, 1999.

Schneider, D.A., Parks, A.H., Eades, S.C. and Tackett, R.L. Palmar Digital Vessel Relaxation in Normal Horses and in Horses Given Carbohydrate. Am. J. Vet. Res. 60: 233-39, 1999.

Holloman, K.A., Dallas, C.E., Jagoe, C.H., Tackett, R.L., Kind, J.A. and Rollor, E.A. Interspecies Differences in Oxidative Stress Response and Radiocesium Levels in Rodents Inhabiting Areas Highly Contaminated by the Chernobyl Nuclear Disaster. Environm. Toxicol. Chem. 19: 2830-34, 2000.

Vishwanathan, K., Tackett, R.L., Stewart, J.T. and Bartlett, M.G. Determination of Arginine and Methylated Arginines in Human Plasma by LC/MS/MS. J Chromatograph B. 748: 157-166, 2000.

Hunt, E.J., Lester, C.E., Lester, E.A. and Tackett, R.L. Effect of St. John's Wort on Free Radical Production. Life Sci. 69: 181-90, 2001.

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