Adviye Ergul, M.D., Ph.D.

Assistant Professor

Clinical and Administrative Pharmacy
University of Georgia College of Pharmacy and
Medical College of Georgia
CJ-1020, Augusta, Georgia 30912-2450
E-mail: aergul@mail.mcg.edu

Education:

1981-1987   M.D.
The University of Instanbul Cerrahpasa Medical School, Istanbul, Turkey
1987-1990   Resident, Clinical Biochemistry
Ministry of Health, Haseki Hospital, Istanbul, Turkey
1990-1995   Ph.D., Department of Biochemistry and Molecular Biology
University of Miami School of Medicine, Miami, Fl
1995-1996   Postdoctoral Associate, Department of Biochemistry and Molecular Biology
University of Georgia, Athens, Ga

Research Interests:

Dr. Ergul`s laboratory is focused on both clinical and experimental research. One project involves the delineation of structural determinants involved in the processing of big endothelin-1 to endothelin-1, the most potent vasoconstrictor substance at present, by endothelin converting enzyme-1. Clinical projects focus on the role of endothelin-1 and its receptors in various clinical settings including coronary artery bypass grafting, chronic occlusive peripheral arterial disease, diabetes and hypertension. Dr. Ergul is particularly interested in the racial and gender factors involved in the regulation of the endothelin system and currently evaluating whether this system contributes to the increased incidence of hypertension and related complications in African American patients using novel endothelin receptor antagonists.

Selected Publications

Ergul, S., Parish, C.D., Puett, D., and Ergul, A. (1996) Racial differences in plasma endothelin-1 concentrations in individuals with essential hypertension. Hypertension 28, 652-655.

Ergul, A., Shoemaker, K., Ricci, S., Puett, D., and Tackett, R.L. (1998) Gender differences in the expression of endothelin receptors in human saphenous veins in vitro. J Pharm Exp Therap 285, 511-517.

Ergul, A., and Puett, D. (1998) Hormone receptors. Encyclopedia of Reproduction (E. Knobil and J. Neill, eds.), Academic Press.

Ergul, S., Ergul, A., Hudson, J. A., Puett, D., Wieman, B.M., Durham, M.D., and Parish, D.C. (1998) The effect of regulation of high blood pressure on plasma endothelin-1 levels in African American hypertensives.Am J Hypertension 11, 1381-1385.

Brooks, C.S., and Ergul, A. (1998) Identification of amino acid residues in the C-terminal tail of big endothelin-1 involved in the processing to endothelin-1. J Mol Endocrinol, 21, 307-315.

Ergul, A., Tackett, R.L., and Puett, D. (1999) Distribution of endothelin receptors in saphenous veins of African Americans: Implications of racial differences. J Cardiovasc Pharmacol, 34, 327-332.

Ergul, A., Walker, C.A., Goldberg, A., Baicu, S.C., Hendrick, J.W., King, M.K., and Spinale, F.G. (2000) ET-1 in myocardial interstitium in heart failure: Relation to myocyte ECE activity and expression. Am J Physiol, 278, H2050-H2056.

Brooks, C.S., Fernandez, L., and Ergul, A. (2000) Secretion of endothelin converting enzyme-1a: the hydrophobic signal anchor domain alone is not sufficient to promote membrane localization. Mol Cell Biochem, 208, 45-51.

Ergul, A. (2000) Hypertension in African-Americans: An emerging role of the endothelin system in salt-sensitive hypertension. Hypertension, 36, 62-65.

Brooks, C.S. and Ergul, A. (2000) Role of the hydrophobic transmembrane domain in membrane anchoring of ECE-1a. J. Cardiovasc. Pharmacol. 36 (Suppl. 1), S30-S32.

Ergul, A., Grubbs, L.A., Zhang, Y., and Spinale, F.G. (2000) Selective upregulation of endothelin converting enzyme-1a in human failing heart. J. Cardiac Fail., 6, 314-320.

Walker, C.A., Baicu, S.C., Goldberg, A.T., Widner, C.E., Fary, D.J., Almany, D.K., Ergul, A., Crawford, F.A., and Spinale, F.G. (2000) Temporal endothelin dynamics of the myocardial interstitium and systemic circulation in cardiopulmonary bypass. J. Thorac. Cardiovasc. Surg., 120, 864-871.

Ergul, A., Grubbs, L.A., Zhang, Y., Joffs, C., Sample, J.A., King, M.K., and Spinale, F.G. (2001) Pulmonary endothelin, endothelin receptors, and endothelin converting enzyme in heart failure: expression and activity. J. Cardiac Fail., 7, 84-91.

Grubbs, L.A. and Ergul, A. (2001) A review of endothelin and hypertension in African-American individuals. Ethnicity & Disease, 11, 741-748.

Walker, C.A., Ergul, A., Grubbs, A., Zile, M.R., Zellner, J.L., Crumbley, A.J., and Spinale, F.G. (2001) beta-adrenergic and endothelin receptor interaction in dilated human cardiomyopathic myocardium. J. Cardiac Fail., 7, 129-137.

Ergul, A., Joffs, C., Walker, C.A., Spinale, F.G. (2001) Potential role of endothelin receptor antagonists in the setting of cardiopulmonary bypass: relevance to myocardial performance. Heart Fail. Revs., 6, 287-294 (invited review).

Ergul, A. (2002) Endothelin-1 and endothelin receptor antagonists as potential cardiovascular therapeutic agents. Pharmacotherapy, 22, 54-65.

Brothers, T.E., Grubbs, A.L., Zhang, Y and Ergul, A. Selective downregulation of endothelin-B receptors in diabetic African-American patients. Ethnicity & Disease, (in press).

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